ECMC's Comprehensive Psychiatric Emergency Program (CPEP) is the only 24-hour psychiatric emergency program in WNY. The treatment team features a multidisciplinary approach, with professionals from psychiatry, psychology, social work, psychiatric nursing, child mental health, chemical dependency and community mental health. Each year, 7,000 people come to CPEP for help, and about 2,800 are admitted on an inpatient basis.

Within the CPEP program, ECMC operates an extended-observation (short-term-stay) unit for patients who require further assessment, treatment and stabilization (with five adult beds and one dedicated for adolescents); a Mobile Crisis Outreach Program, which provides medical or psychiatric evaluation and treatment in the patient's home by qualified mental health professionals; a Crisis Residence Program, which offers short-term emergency housing to patients who have mental illness but are capable of self-supervision; counseling support and medication management for follow-up services to CPEP patients; Children's Services, including an Adolescent Inpatient Unit; and a referral program, which provides ongoing support and linkage to various community outpatient services.